U-48800 is an extremely strong opioid agonist that is structurally distinct from fentanyl and has been linked to opioid overdoses and deaths. Novel synthetic opioids (NSOs) with no acknowledged therapeutic application, such as U-48800, are clandestinely made and marketed on the conventional or dark web. This Certified Spiking Solution® is suitable for use in LC-MS/MS or GC/MS urine drug testing, clinical toxicology, or forensic analytical applications.
U-47700, U-49900, AH-7921, MT-45, new synthetic opioids, toxicity, health risk

This Cerilliant product is part of the Centers for Disease Control and Prevention (CDC) Opioid CRM Kit, which includes over 40 CRMs for use in the CDC′s laboratory response to the opioid epidemic. The kits are given to drug testing laboratories in the United States for free. A seeking lab must be DEA registered and follow all applicable state and local rules. For more information on requesting a free Opioid CRM Kit, go to www.cerilliant.com. Please keep in mind that all order requests will be reviewed and approved by CDC.

A class of opioid agonists that are not structurally linked to fentanyl and are developed from pharmaceutical company research articles or patents in the United States and overseas are adding to the present opioid epidemic. Novel synthetic opioids (NSOs) with no acknowledged therapeutic application, such as U-47700, U-49900, AH-7921, or MT-45, are clandestinely synthesized and marketed on the conventional or dark web.

We present a review of the pharmacological properties available on the majority of these chemicals in order to provide a better understanding of these compounds, particularly in terms of toxicity and serious side effects in users. Indeed, these NSOs share not only a high potency of action and receptor affinity with natural or synthetic opiates (e.g., morphine, heroin, and methadone), but also a high toxicity that leads to intoxications and fatalities, posing a severe threat to public health and society.

U-48800 is an extremely strong opioid agonist that is structurally distinct from fentanyl and has been linked to opioid overdoses and deaths. Novel synthetic opioids (NSOs) with no acknowledged therapeutic application, such as U-48800, are clandestinely made and marketed on the conventional or dark web. This Certified Spiking Solution® is suitable for use in LC-MS/MS or GC/MS urine drug testing, clinical toxicology, or forensic analytical applications.

This Cerilliant product is part of the Centers for Disease Control and Prevention’s (CDC) Opioid CRM Kit, which includes over 40 CRMs for use in the CDC’s laboratory response to the opioid epidemic. The kits are given to drug testing laboratories in the United States for free. A seeking lab must be DEA registered and follow all applicable state and local rules. For more information on requesting a free Opioid CRM Kit, go to www.cerilliant.com. Please keep in mind that CDC will examine and authorize all order requests before they are shipped.