Dimethocaine is a local anesthetic with the potential for abuse due to its action being comparable to cocaine. With an IC50 of 1.2 M, this chemical totally blocks dopamine absorption in rat striatal synaptosomes, similar to cocaine (IC50 = 0.7 M). 1 As a result, dimethocaine substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys in a dose-dependent manner. 2,3 This item is for forensic and research purposes only.
Technical Specifications
3-(diethylamino)-2,2-dimethyl-1-piperazine (4-aminobenzoate)
monohydrochloride of 1-propanol
553-63-9 CAS Number
• HCl Formula Weight 314.9 Purity 98 percent Molecular Formula C16H26N2O2
Formulation a crystalline substance

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Dimethocaine, commonly known as DMC or larocaine, is a stimulant. Although dimethocaine looks to be less strong than cocaine, it has a similar impact. Dimethocaine, like cocaine, is addictive because it stimulates the brain’s reward circuit.
Dimethocaine is a legal cocaine substitute in several countries, and it is even classified as “synthetic cocaine derivatives” by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA).
A local anesthetic with the potential for abuse due to its action similar to cocaine; totally inhibits dopamine uptake in rat striatal synaptosomes with an IC50 value (1.2 M) comparable to cocaine (IC50 = 0.7 M); substitutes for cocaine in drug discrimination tests in rats and rhesus monkeys.