U-48800 is a structurally comparable to known opioids analytical reference substance. This product is meant for forensic and research purposes. This is a qualified Reference Material (RM) that has been manufactured and tested in accordance with ISO/IEC 17025 and ISO Guide 34 standards. To ensure measurement traceability, these materials are analyzed using recognized analytical procedures on authorized apparatus.
We present a method for detecting and quantifying 12 substances and 2 metabolites in human whole blood that belong to the same structural class as the illegal mu-opioid agonist U-47700. These compounds are either known or suspected of being prevalent in illegal drug markets as potential new opioids. The main class of these medications was established in pharmaceutical research programs in the 1970s, but they have recently been a source of worry for opioid overdoses and mortality in the United States and around the world.
The following chemicals were examined: methylenedioxy U-47700, ethylenedioxy U-47700, ethylenedioxy U-51754, U-69593, U-47931E (bromadoline), U-47700, U-48800, U-49900, U-51754, U-50488, propyl U-47700, and isopropyl U-47700. The scope also included the two metabolites N,N-didesmethyl U-47700 and desmethyl U-47700. Solid-phase extraction was used to extract drugs from human whole blood, and the extracts were evaluated using liquid chromatography—tandem mass spectrometry.
The assay was verified in terms of bias, carryover, interference, precision within and between runs, and accuracy. This method was used to successfully confirm and quantify eight medicolegal death investigation cases that had tested positive for U-48800 by liquid chromatography—time-of-flight mass spectrometry. The mean and median U-48800 concentrations in these patients were 2.5 (2.1) and 1.8 ng/mL, respectively, with a concentration range of 0.27-6.2 ng/mL. Case history information is described and reviewed, including the presence of various medicines in combination.
U-47700, sometimes known as “U4,” “pink,” or “pinky,” is an extremely strong synthetic opioid that has the appearance of white or light pink powder. It is frequently sold in baggies or squeezed into tablets to resemble legal medications. This substance is abused in the same way as heroin, prescription and designer opioids are.
Novel synthetic opioids (NSO) are a newly emerging class of psychoactive drugs (NPS). Fentanyl (e.g., acetylfentanyl, ocfentanil, carfentanil, furanylfentanyl, fluorofentanyl) and non-fentanyl analogs are among them.
