U-48800 (hydrochloride)

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Description

U-48800

U-48800 is an analytical reference material that is structurally similar to known opioids. This product is intended for research and forensic applications.
This product is a qualified Reference Material (RM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO Guide 34 guidelines. These materials are tested using validated analytical methods on qualified instrumentation to ensure traceability of measurements. All traceable RMs may be distinguished by their CofAs and can be downloaded below using the batch number located on the product label. For a representative CofA please contact our technical support.
WARNING This product is not for human or veterinary use.

We report a method for the detection and quantitation of twelve drugs and two metabolites in the same structural class as the illicit mu-opioid agonist U-47700 in human whole blood. These substances are either known or suspected to be present as potential novel opioids in illicit drug markets. The general class of these drugs was developed in pharmaceutical research programs in the 1970’s but have recently become of concern for overdoses and death in opioid users in the United States and internationally. The scope of analysis included the following compounds: methylenedioxy U-47700, ethylenedioxy U-47700, ethylenedioxy U-51754, U-69593, U-47931E (Bromadoline), U-47700, U-48800, U-49900, U-51754, U-50488, propyl U-47700, and isopropyl U-47700. Additionally, two metabolites, N,N-didesmethyl U-47700, desmethyl U-47700 were also included in the scope. Drugs were extracted from human whole blood using solid phase extraction (SPE) and the extracts were analyzed by liquid chromatography tandem mass spectrometry (LCMSMS). The assay was validated with respect to bias, carryover, interference, and within run and between run precision, and accuracy. Eight medicolegal death investigation cases which had screened positive for U-48800 by liquid chromatography time-of-flight mass spectrometry (LCTOF) were successfully confirmed and quantified using this method. The mean and median concentrations of U-48800 in these cases were 2.5 (±2.1) ng/mL and 1.8 ng/mL, respectively, with a range of concentrations of 0.27-6.2 ng/mL. Case history information including the presence of other drugs in combination are described and discussed.

Reference standards for methylenedioxy U-47700, ethylenedioxy U-47700, ethylenedioxy U-51754, U-69593, U-47931E (bromadoline), N,N-didesmethyl U-47700, desmethyl U-47700, U-47700, U-48800, U-49900, U-51754, U-50488, propyl U-47700 and isopropyl U-47700 were purchased from Cayman Chemical (Ann Arbor, MI). Isotopically labeled internal standards U-47700 D3, U-51754 D3 and desmethyl U-47700 D3 were also purchased from Cayman Chemical. Solid-phase extraction (SPE) columns, 130 mg Clean Screen® DAU, were purchased from UCT (Bristol, PA). Liquid chromatography mass spectrometry solvents were purchased from Honeywell (Muskegon, MI) and included the following: water, acetonitrile and methanol. Ammonium formate was purchased from Alfa Aesar (Ward Hill, MA), and formic acid was purchased from Life Technologies Corporation (Carlsbad, CA).

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