Formal Name: 4-(2-chlorophenyl)-2-ethyl-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine
CAS Number: 40054-69-1
Molecular Formula: C17H15ClN4S
Formula Weight: 342.8
Purity: ≥98%
Formulation: A neat solid
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Etizolam is a psychoactive benzodiazepine analog with certain medical applications that reportedly has been abused.1 It acts as a full agonist of benzodiazepine receptors.2 This product is intended for forensic and research applications. Get it from Fire Brand Chems
WARNING This product is not for human or veterinary use.

Etizolam is a thienodiazepine which is chemically related to benzodiazepine (BDZ) drug class; it differs from BDZs in having a benzene ring replaced with a thiophene ring. It is an agonist at GABA-A receptors and possesses amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties. Initially introduced in 1983 in Japan as treatment for neurological conditions such as anxiety and sleep disorders, etizolam is marketed in Japan, Italy and India. It is not approved for use by FDA in the US; however it remains unscheduled in several states and is legal for research purposes.

Etizolam is a CNS depressant with anxiolytic, anticonvulsant, sedative-hypnotic and muscle relaxant effects. It acts on the benzodiazepine site of the GABA-A receptor as an agonist to increase inhibitory GABAergic transmission throughout the central nervous system. Studies indicate that etizolam mediates its pharmacological actions with 6 to 10 times more potency than that of diazepam. Clinical human studies performed in Italy showed clinical effectiveness of etizolam in relieving symptoms in patients with generalized anxiety disorders with depressive symptoms 2,3,4. Etizolam also mediates imipramine-like neuropharmacological and behavioral effects, as well as minor effects on cognitive functioning. It is shown to substitute the actions of a short-acting barbiturate, pentobarbitol, in a drug discrimination study 8. Etizolam is an antagonist at platelet-activating-factor (PAF) receptor and attenuates the recurrence of chronic subdural hematoma after neurosurgery in clinical studies 9. It is shown to inhibit PAF-induced bronchoconstriction and hypotension 5.

Arophalm (Nichi-Iko Pharmaceutical) / Capsafe (Ohara Yakuhin) / Dezolam (Taisho Yakuhin) / E1 (Aarpik) / Eticalm (Towa Yakuhin) / Etisedan (Kyowa Yakuhin) / Etizolan (Kobayashi Kako) / Mozun (Tatsumi Kagaku) / New Zomnia (Molekule) / Nonnerv (Nisshin Pharmaceutical) / Palgin (Fujinaga Seiyaku) / Sylkam (Dr. Reddy’s)

This compound belongs to the class of organic compounds known as thienodiazepines. These are heteropolycyclic containing a thiophene ring fused to a diazepine ring. Thiophene is 5-membered ring consisting of four carbon and one sulfur atoms. Diazepine is a 7-membered ring consisting of five carbon and two nitrogen atoms.

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