5F-AKB48 (also known as 5F-APINACA) is an indazole-based synthetic cannabinoid that has been sold online as a designer drug.



5F-AKB48 (also known as 5F-APINACA and AKB-48F) is a synthetic cannabinoid substance of the indazolecarboxamide class. It acts as a potent agonist for the CB1 and CB2 cannabinoid receptors. It was first identified in South Korea and is available for sale as a grey area research chemical through online vendors. Its abuse has been associated with multiple serious injuries deaths and more dangerous side effects and toxicity in general.

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Here we have the purest form of 5F-AKB48. Although this substance has not been formally studied, from analysis of the structure, it is presumed that 5F-AKB48 has a similar binding profile to that of other cannabinoids and matches many of the in vivo properties of Δ9-THC. However, the role of these interactions and how they result in the cannabinoid high continues to remain elusive.

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Rationale: AKB48 and its fluorinate derivate 5F-AKB48 are two novel synthetic cannabinoids belonging to a structural class with an indazole core structure. They are marketed as incense, herbal preparations or chemical supply for their psychoactive Cannabis-like effects.


Objectives: The present study was aimed at investigating the in vitro and in vivo pharmacological activity of AKB48 and 5F-AKB48 in male CD-1 mice and comparing their in vivo effects with those caused by the administration of Δ9-THC and JWH-018.

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Results: In vitro competition binding experiments performed on mouse and human CB1 and CB2 receptors revealed a nanomolar affinity and potency of the AKB48 and 5F-AKB48. In vivo studies showed that AKB48 and 5F-AKB48, induced hypothermia, increased pain threshold to both noxious mechanical and thermal stimuli, caused catalepsy, reduced motor activity, impaired sensorimotor responses (visual, acoustic and tactile), caused seizures, myoclonia, hyperreflexia and promoted aggressiveness in mice.

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Conclusions: For the first time, the present study demonstrates the overall pharmacological effects induced by the administration of AKB48 and 5F-AKB48 in mice and suggests that the fluorination can increase the power and/or effectiveness of SCBs. Furthermore, this study outlines the potential detrimental effects of SCBs on human health.

Keywords: 5F-AKB48; AKB48; Behavior; Cannabinoids; JWH-018; Microdialysis; Sensorimotor responses; Synthetic cannabinoids; Δ9-THC.

A synthetic cannabanoid that is a Indazole. Produces subjective effects somehwat similar to that of Cannabis, yet with a very short duration. Analogue of STS-135, in which the core indole structure is subbed with an indazole base.

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1000g, 100g, 10g, 250g, 500g, 50g


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