5C ABP

$150.00$2,650.00

Iupac name: N-(1-carbamoyl-2-methylpropyl)-1-(5-chloropentyl)-1H-indazole-3-carboxamide

Chemical Formula: C18H25ClN4O2

Exact Mass: 364.17

Molecular Weight: 364.87

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Description

5C ABP

5C ABP-PINACA(5C-ABP) is an indazole-based synthetic can that is derived from a series of compounds originally developed by Pfizer in 2009 as an analgesic medication and has been sold online as a designer drug. This product is intended for laboratory research purposes only and is not to be used for any other purposes.
The substance is one of the latest products of our specialists. Its formula was improved and researched and now it is ready to be sold online. To provide our customers with the opportunity to test the substance our online vendor offers to purchase online a sample of this legal powder at a reasonable price and free delivery.
For the smaller research chemicals suppliers which are intended to resell the substance, we can consider the wholesale terms of collaboration in order to promote the substance at the research chemicals market and among the clients. You can also figure out a lot of other already well-known designer chemicals for sale on our website.

Background: Activated intermediates of 4-aminobiphenyl (4-ABP) are able to covalently interact with DNA to form adducts. There is a large body of evidence indicating that carcinogen-DNA adduct formation can be one of the cancer initiating mechanisms.

Materials and methods: (4-ABP)-induced DNA damage in association with p53 overexpression and mutations were evaluated in specimens of urothelial bladder cancers from 106 patients.

Results: 4-ABP-DNA adduct levels resulted higher in smokers compared to non smokers, with a borderline statistical value. p53 nuclear overexpression was related to tumor grading, while no significant correlation with stage, 4-ABP-DNA adducts, smoking habit, and disease recurrence could be observed. Concerning molecular analysis, p53 point mutations were found in 17 of 106 cases (16%) and mutational pattern was significantly associated both with higher grade and stage, but no correlation was found with disease recurrence.

Conclusions: These results suggest that other sources, in addition to tobacco smoke, may contribute to 4-ABP-DNA adducts formation in bladder tissue and that p53 expression/mutation cannot be considered a prognostic factor in bladder cancer.

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1000g, 100g, 10g, 250g, 500g, 50g

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