5-methoxy DMT (5-MeO-DMT)


Formal Name: 5-methoxy-N,N-dimethyl-1H-indole-3-ethanamine

CAS Number: 1019-45-0

Molecular Formula: C13H18N2O

Formula Weight: 218.3

Purity: ≥98%

Formulation: A crystalline solid

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5-methoxy DMT (5-MeO-DMT) is a naturally-occurring hallucinogenic indolealkylamine that potently activates serotonin (5-HT) receptors.1,2 Although this compound is regulated in many countries, including the United States, it has been described as an ‘emerging psychoactive substance’ found in party pills and related mixtures.3 As 5-methoxy DMT is inactivated by monoamine oxidases, inhibitors of monoamine oxidases are often combined with 5-methoxy DMT to prolong its activity.4,5 The pharmacological and toxicological properties of this compound have been recently reviewed.6 This product is intended for forensic applications. .
WARNING This product is not for human or veterinary use.

To support clinical use, a multigram-scale process has been developed to provide 5-MeO-DMT, a psychedelic natural product found in the parotid gland secretions of the toad, Incilius alvarius. Several synthetic routes were initially explored, and the selected process featured an optimized Fischer indole reaction to 5-MeO-DMT freebase in high-yield, from which the 1:1 succinate salt was produced to provide 136 g of crystalline active pharmaceutical ingredient (API) with 99.86% peak area by high-performance liquid chromatography (HPLC) and a net yield of 49%. The report provides in-process monitoring, validated analytical methods, impurity formation and removal, and solid-state characterization of the API essential for subsequent clinical development.

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