N-Ethylhexedrone, also more commonly known as Hexen, N-Ethyl-nor-hexedrone, and NEH, is a synthetic stimulator of the cathinone chemical class. This type of drug is principally an active constituent of the khat plant, and is constituted of a phenethylamine core with an alkyl group attached at the alpha carbon and an oxygen group attached to the beta carbon. These can also be modified in various ways to create hundreds of different compounds.
N-ethyl Heptedrone is a substituted cathinone and a new stimulant.
The structure of substituted cathinones is based on the structure of cathinone, an alkaloid found in the Khat plant. Novel stimulants with stimulant-like properties, similar to amphetamines, have been described. According to the literature, novel stimulants have also produced adverse outcomes, including deaths. N-ethyl hexedrone, hexedrone, and pentedrone are all structurally related chemicals. In the United States, pentedrone and N-ethyl hexedrone are Schedule I chemicals; however, hexedrone and N-ethyl heptedrone are not.
N-Ethyl pentylone (NEP) is a chemical derivative of cathinone. Synthetic cathinones are a new class of medicines having stimulating, mind-altering effects. They are also known as novel or new psychoactive compounds (NPS). In the medical literature, there is little information about forensic cases in which NEP is discovered in toxicological testing. In 2017, four NEP-related fatalities occurred in Alabama. NEP toxicity was ascribed to death in two cases (peripheral blood concentrations of 0.121 and 0.953 mg/L) and gunshot wound injuries in two cases (peripheral blood concentrations of 0.045 and 0.031 mg/L). One NEP case documented an individual who displayed classic CNS-stimulant caused erratic behavior before being discovered dead.These cases enhance the forensic literature regarding specific NPS like NEP and provide contextual reference for professionals considering the significance of NEP in toxicological interpretation.
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excited delirium; forensic science; forensic toxicology; n-ethyl pentylone; novel psychoactive substance; toxicological interpretation.