Methoxetamine (MXE) is a dissociative drug, which means it makes people feel disconnected from their bodies and surroundings. Dissociatives are comparable to psychedelics in that they can create hallucinations and other mental, emotional, and spiritual alterations.
MXE is also known by the names M-ket, Kmax, and Mexxy.
MXE is a New Psychoactive Substance as well (NPS). NPSs are a class of drugs created to mimic the effects of illegal substances. MXE, for example, seeks to mimic the effects of ketamine and has been marketed and sold as a legal substitute online. NPSs are, however, prohibited in some states and territories.

One of the new “legal highs” marketed on the Internet is methoxetamine (MXE), a ketamine analogue. The goal of this qualitative study was to gain an initial grasp of what distinguishes MXE-induced experiences. The Empirical Phenomenological Psychological Method was used to assess anonymously written reports on the effects of MXE acquired from public Internet forums (33 people). Ten topics emerged from the research: (1) initial effects; (2) malfunction of cognitive processes stabilizing normal state; (4) inner personal processes and learning; (5) emotional processes; (6) altered sensory perception; (7) dissolution and transition; (8) spiritual and transcendental experiences; (9) effects and processes after the experience; (10) re-dosing and addiction

MXE caused a significant shift in consciousness. Classic hallucinogens (such as LSD and psilocybin) and the dissociative ketamine produced similar results. MXE seems to have a high potential for abuse. Aside from the beneficial impacts, negative effects such as worry and anxiety were also mentioned. Acceptance was seen as the most effective coping method. Spiritual and transcendental experiences frequently resulted from the dissolution of identity and body. More research is needed into safety concerns, how to reduce harm, and why people use legal highs.
ASC, hallucinogen, Internet drug, legal high, methoxetamine, MXE, and psychedelic
MXE use is more likely to be hazardous when:

when used with alcohol or other drugs, including over-the-counter and prescription pharmaceuticals
When driving or operating large machinery, individual judgment and motor coordination are necessary (in case medical assistance is required)
The individual has a mental health issue.
The individual already has a heart condition.
Drug injections, especially MXE, can harm veins and other tissues.
Sharing needles could also spread:
Hepatitis B Tetanus
Hepatitis C is a virus that causes liver disease.
HIV/AIDS.
Tolerance and dependence

Although there is little evidence linking MXE to addiction, experts believe that its closeness to ketamine suggests it has a similar risk of addiction. While the UK’s Independent Scientific Committee on Drugs considers ketamine to be less hazardous than other illicit drugs like methamphetamine, heroin, cocaine, or GHB,13 certain studies have found a substantial risk of tolerance and addiction.
Effects on the urinary tract
MXE appears to produce similar bladder and urinary tract difficulties to ketamine when used frequently and for long periods of time. Ketamine-induced cystitis can be life-threatening and is a painful illness that requires constant therapy. 2 Anyone experiencing bladder or urinary tract issues should cease using MXE and seek medical help.