MAM2201 and any other research chemical drugs sold on this site are for forensic and research purposes only. MAM-2201, a research chemical with the molecular formula C25H24FNO, is a designer drug having strong physiological and psychotropic effects. The weight of the formula is 373.5 g/mol.
MAM2201’s toxicological and physiological properties are unknown. MAM-2201 and other synthetic cannabinoids may have a high affinity for peripheral CB1 and CB2 cannabinoid receptors.
MAM-2201 (4″-methyl-AM-2201, 5-fluoro-JWH-122) is a medication that is thought to work as a cannabinoid receptor agonist.
MAM-2201 (4′-methyl-AM-2201, 5′′-fluoro-JWH-122) is a medication that is thought to work as a cannabinoid receptor agonist. It was initially found as a component in synthetic cannabis smoking mixtures by laboratories in the Netherlands and Germany in June 2011. It had never been mentioned in the scientific or patent literature before.
It appears to be an unique molecule created by “research chemical” vendors expressly for grey-market recreational usage, similar to RCS-4 and AB-001. It’s a cross between two well-known cannabinoid chemicals, JWH-122 and AM-2201, which were formerly employed as active elements in synthetic cannabis blends before being outlawed in many countries.
Fluorinated synthetic cannabis analogs are increasingly being used to circumvent existing legal restrictions around the world. MAM-2201, a fluorinated JWH-122 derivative, was initially identified as a component in herbal combinations in Korea in September 2012. MAM-2201 is more potent than JWH-122, and it has been linked to a fatal overdose. In this investigation, we compared the results of in vitro metabolism studies utilizing human liver microsomes with those of urine specimens from suspected MAM-2201 or JWH-122 users to identify key MAM-2201 and JWH-122 metabolites. N-5-hydroxylated, N-4-hydroxylated, and carboxylated JWH-122 metabolites were generated by MAM-2201 and JWH-122.
Only a few urine specimens from MAM-2201 users contained trace quantities of an N-4-hydroxylated MAM-2201 metabolite, a typical MAM-2201 metabolite. N-5-hydroxylated JWH-122 metabolite was the principal metabolite of MAM-2201 in both in vitro and in vivo experiments, whereas N-4-hydroxylated JWH-122 metabolite was prominent in JWH-122 metabolism. Relative concentrations of N-5- and N-4-hydroxylated JWH-122 metabolites should be examined to validate MAM-2201 or JWH-122 users based on these findings.