Synthetic cannabinoids are increasingly being used recreationally. This rise can be attributed in part to the recent availability of low-cost compound sold in bulk lawfully online. In herbal mixtures promoted as alternatives to cannabis, JWH-018 (1-pentyl-3-(1-naphthoyl)indole) and JWH-073 (1-butyl-3-(1-naphthoyl)indole) have been discovered. Despite the fact that these compounds were recently urgently scheduled in the US, internet vendors have moved sales to other, similar compounds that are not now scheduled. The purity of medications bought from online providers, however, is unknown. Using high-performance liquid chromatography with ultraviolet detection and verified standards supplied from a traditional research chemical supplier, the relative purity of JWH-018 and JWH-073 from three separate online providers was assessed.
Even though the physical features of JWH-018 and JWH-073 bought from online vendors differed in color, texture, and odor, our findings suggest that they were of equivalent purity to verified criteria. It is concluded that adverse reactions to synthetic cannabinoid preparations are more likely due to effects of the active drug or interactions with other psychoactive chemicals from herbs blended into products marketed as cannabis alternatives, rather than impurities or residue from the manufacturing process.
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