JWH-018 is a synthetic cannabinoid agonist that lacks the traditional chemical structure of cannabinoids. It was utilized as a tool in scientific research to examine the cannabinoid system.
JWH-018 has been found in herbal incense blends.featuring names like “Spice,” “K2,” and others, sold through the Internet access, gas stations, convenience stores, and cigarette stores and marijuana dispensaries
JWH-018 was created and used in basic scientific research to investigate structure-activity correlations in cannabinoid receptors.
JWH-018 is intentionally spiked on plant material and has no known legitimate usage outside of research. It has been found in a variety of herbal incense products, including “Spice,” “K2,” and other similar items smoked for their euphoric effects.
JWH-018, also known as 1-pentyl-3-(1-naphthoyl)indole or AM-678, is an analgesic chemical that produces in animals effects similar to those of tetrahydrocannabinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products sold legally as “incense blends” in some countries.
IUPAC: Naphthalen-1-yl-(1-pentylindol-3-yl)methanone
Molecular Formula: C24H23NO
CAS#: 209414-07-3
Appearance: White Powder
Purity: 99%
This drug may cause a heightened mood, enhanced sense of humour, heightened curiosity and intrigue, racing thoughts, time distortion and dilation, buzzing or humming like a psychedelic experience, reduced concentration, a relaxing state, mild euphoria (phasing in between bouts), Manic-depressive symptoms, and other side effects (hyperactivity to moments of dullness and vice versa).
JWH-018 is a synthetic cannabinoid included in various variations of the herbal blend “Spice.” While significantly more potent than comparable amounts of cannabis, JWH-018 poses considerable hurdles for detection by standard 9-THC testing methods.
The most often used recreational drugs are natural cannabinoids and their synthetic counterparts. Numerous clinical instances show severe toxic symptoms and neurological effects after inhaling the “Spice” mixture of synthetic cannabinoids. The natural cannabinoid 9-tetrahydrocannabinol (10 mg/kg), one of the primary constituents of marijuana, or the synthetic cannabinoid JWH-018 (2.5 mg/kg) induced electrographic seizures in mice, as measured by electroencephalography and videography.
JWH-018 (1.5, 2.5, and 5 mg/kg) administration enhanced seizure spikes dose-dependently. AM-251 (5 mg/kg), a cannabinoid receptor 1-selective antagonist, totally prevented cannabis-induced seizures in mice. These findings suggest that cannabis usage is hazardous and poses a new public health risk. Furthermore, our findings strongly imply that AM-251 could be employed as an important preventative medication for cannabinoid-induced seizures or other potentially fatal disorders.
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