Synthetic cannabinoids (SCs) are one of many new psychoactive drugs available on the illicit drug market, and they are among the substances that have caused major side effects and death. However, information on common drug concentrations is limited. APINACA and 5F-APINACA concentrations in biological matrixes have never been recorded, while UR-144 and its degradant product concentrations in blood samples from driving under the influence of drugs (DUID) instances have never been published. The goal of this study was to present APINACA, 5F-APINACA, UR-144, and UR-144 degradant concentrations from DUID cases evaluated at the Norwegian Institute of Public Health (NIPH), as well as previously unpublished AM-2201 findings in cases from our Institute.
We’ve also compiled a list of all previous published research that provided SC concentrations to compare with the results from these newer SCs. We discovered 5F-APINACA in one driver’s whole blood and APINACA and 5F-APINACA in three drivers’ whole blood in concentrations ranging from 0.24 to 24.5 and 0.9 to 6.5 g/L, respectively, and UR-144 in two cases in values of 0.22 and 0.47 g/L. One of the instances included UR-144 degradant at a concentration of 0.15 g/L. A review of the literature finds significant flaws in the concentrations of most SCs. (n8) AM-2201, JWH-122, JWH-018, and JWH-210 were the SCs found most frequently in DUID cases.
Four investigations on concentrations in autopsy cases have been published, with four distinct SC concentrations found (JWH-018, JWH-073, JWH-210, AM-2201 and the metabolites of AM-2201; 4-OH-pentyl, JWH-018 5-OH-pentyl and JWH-018 pentanoic acid). Only JWH-018 (n=3), JWH-073 (n=1), and the AM-2201 metabolites 4-OH-pentyl, 6-OH-indole, JWH-018 5-OH-pentyl, and JWH-018 pentanoic acid (n=1) have pharmacokinetic data.
It’s the most closely related synthetic cannabinoid to the “high” produced by cannabis. Those who have tried it claim an extremely addicting sensation that is unlike anything else. It is recommended that users start with minimal doses of this medication. The drug’s effects begin slowly, but after a while, the user develops a strong desire to drink more. Users who take large dosages of the medication may experience stronger effects.
With moderate paranoia, the euphoric effects of this substance reach a high level in less than 20 minutes. The medicine causes the person to become relaxed and dizzy.
According to reports, when you buy 5Fur-144 online and utilize it, it works rapidly and has a hallucinogenic effect. It can also cause blurred vision in certain people. All of this, however, is dependent on the dosage given. While some people report negative side effects, others claim that the medicine works well and gives them a buzz. Online auction for 5Fur-144 .
