The strong alkylindole synthetic cannabinoids UR-144 and its halogenated derivative 5F-UR-144 (XLR-11) have recently been discovered in herbal combinations with tobacco, incense, and potpourri. The pharmacology, toxicokinetics, and clinical consequences of several medications are discussed in this presentation. Information was found by searching PubMed (the US National Library of Medicine) and official websites without regard to time limits. The majority of information on UR-144 and XLR-11 comes from clinical and forensic intoxication reports.
Although the mechanisms causing their toxicity have yet to be fully understood, there is evidence of a significant number of hospitalizations that culminated in death as a result of acute exposure. An increase in muscular tone, high systolic blood pressure, anxiety, confused speech, decreased coordination, hallucinations, irritability, convulsions, tachycardia, and chest pain are all indications of intoxication. Autopsies frequently reveal acute kidney disease (acute tubular injury and interstitial nephritis), pulmonary oedema, cerebral stroke, and myocardial ischemia. UR-144 has a high affinity for the CB2 receptor but a low affinity for the CB1 receptor, whereas XLR-11 acts as a powerful agonist for both cannabinoid receptors.
Monohydroxylation, dihydroxylation, and/or N-pentanoic acid production products were among the most prevalent metabolites found in human urine. UR-144 and XLR-11 are mostly processed in the liver, with CYP3A4 playing a key role. However, it is still unknown how much these metabolic responses play a role in drug (de)toxication. Further clinical and forensic toxicological research are needed to learn more about the long-term effects of UR-144 and XLR-11, as well as their relative metabolites, and how interindividual differences may influence their toxicity.
We recognize it as a component found in synthetic cannabis smoking mixtures. However, consumers advertise it in the black market for recreational purposes. Because it is a novel medicine, users should learn more about its long-term implications. Despite this, it is quickly being known as a very addictive substance.
5fur-144 has been linked to acute renal injury in some users, according to continuing research on psychoactive cannabis compounds.
It is consumed in a combination with equal or smaller amounts of other cannabinoids. 20mg combined with some food is plenty stone.